Cardioprotective effect of cedrol in an inflammation systemic model induced by lipopolysaccharide: Biochemical and histological verification

Seyed Hamidreza Rastegar-Moghaddam ¹ , Sabiheh Amirahmadi ², Mahsan Akbarian ³, Matin Sharizina ⁴, Farimah Beheshti ^5,6, Arezoo Rajabian ⁷, Mohammad Hosein Eshaghi Ghalibaf ², Mohaddeseh Azimi ³, Maryam Mahmoudabady ^3,5, Mahmoud Hosseini ^2,3,7 *

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1- Sajad M, Ali R, Kumar R, Khan N, Wahab S, Alshehri S, Thakur S. Therapeutic potential of cedrol in alleviating cognitive impairments in aluminum chloride-induced Alzheimer's disease: A biomarker-based approach. Results in Chemistry. 2025;16:102487 [Crossref]

2- Tao S, Yu L, Li J, Zhang Z, Liu Y, Wu J, Xia X, Xie Z, Tan Y. Qishen Yangxin Granule ameliorates cardiac function and ventricular remodeling in dilated cardiomyopathy by attenuating inflammation and myocardial fibrosis. Phytomedicine. 2026;162:158878 [Crossref]

3- Hosseini M, Forouzanfar F, Beheshti F, Anaeigoudari A. Cedrol Improved Liver and Kidney Injuries in Lipopolysaccharide-Exposed Rats. 2025;14(1) [Crossref]

4- Liu J, Liu M, Peng L, He H, Sun R, Chang W. Effects of inhaling Cunninghamia lanceolata essential oil on the physiological and psychological relaxation of university students. Front Psychol. 2025;16 [Crossref]

5- Cui X, Tian X, Li X, Zhang X, Wu J. Cedrol mitigates atherosclerosis by inhibiting foam cell formation and inflammatory response via suppression of NOD-like receptor family pyrin domain containing 3 inflammasome. 2026; [Crossref]

6- Fu B, Li X, Zhou J, Lu Y, Yang Y, Li W, Zhou P. Recognition mechanism between subject and guest molecules: separation of cedrol from Chinese fir essential oil via β-Cyclodextrin. Journal of Molecular Structure. 2026;1355:144981 [Crossref]

7- Behrouz S, Hosseini M, Rezaee R, Boskabady M, Asgharzadeh F, Gholamnezhad Z. Cedrol ameliorates lipopolysaccharide-induced systemic inflammation and lung injury in rats. European Journal of Pharmacology. 2025;1003:177952 [Crossref]

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