Logo-jcvtr
Submitted: 16 Dec 2016
Revision: 10 Apr 2017
Accepted: 29 May 2017
ePublished: 12 Jun 2017
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)

J Cardiovasc Thorac Res. 2017;9(2): 78-84.
doi: 10.15171/jcvtr.2017.13
PMID: 28740626
PMCID: PMC5516055
  Abstract View: 1636
  PDF Download: 992

Original Article

Fatty acids composition of aorta and saphenous vein tissues in patients with coronary artery diseases

Mirhamid Paytakhti Oskouei 1,2, Masoud Pezeshkian 1, Naser Safaie 1, Masoud Darabi 2, Amir Fattahi 2, Hossain Bijanpour 1, Maghsod Shaaker 2, Ahmad Reza Jodati 1*, Mohammad Nouri 1*

1 Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
2 Department of Clinical Biochemistry, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
*Corresponding Authors: Email: arjodati@yahoo.com; Email: nourimd@yahoo.com

Abstract

Introduction: Considering importance of fatty acids in developing coronary artery disease (CAD) and lack of information about saphenous vein which is commonly used as coronary arterial bypass, in this study we investigated differences in fatty acids composition between saphenous vein and aorta tissues in patients with CAD.
Methods:
Biopsy samples of aortic tissues and saphenous veins as well as blood samples were obtained form 42 patients with CAD.  Fatty acids composition of the tissues was determined using gas chromatography and also serum lipid profile was evaluated by commercial kits.
Results:
Levels of palmitic acid (16:0) were significantly higher in aorta in compared with saphenous (P < 0.001). Also levels of most unsaturated fatty acids (16:1, 18:1n-9, 18:1t, 18:2t, 18:3 n‐9 and 22:3n-3) were statistically higher in saphenous tissue than aorta tissue (P < 0.05). Mean levels of linoleic acid (18:2 n‐6) was higher in aorta tissue in comparison with saphenous tissue (P = 0.01). We observed positive correlations between serum levels of LDL-C with elaidic acid and linoleic acid levels in saphenous.  Evaluation of aorta tissue fatty acids revealed that palmitoleic acid (16:1) had positive and arachidonic and linoleic acids had negative correlations with serum HDL-C levels.
Conclusion: Our results revealed difference between fatty acids composition of aorta and saphenous vein tissues and existence of correlations between the fatty acids levels with serum lipid profile. The saphenous vein had higher poly-unsaturated fatty acids in compared to aorta tissue and thus this vein is not at risk of atherosclerosis and can be used as coronary arterial bypass.
First Name
 
Last Name
 
Email Address
 
Comments
 
Security code


Abstract View: 1637

Your browser does not support the canvas element.


PDF Download: 992

Your browser does not support the canvas element.