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J Cardiovasc Thorac Res. 2020;12(3): 185-194.
doi: 10.34172/jcvtr.2020.32
  Abstract View: 88
  PDF Download: 111

Original Article

The combined effects of cholesteryl ester transfer protein (CETP) TaqIB gene polymorphism and canola, sesame and sesame-canola oils consumption on metabolic response in patients with diabetes and healthy people

Nahid Ramezani-Jolfaie 1,2 ORCID logo, Shiva Aghaei 3, Ehsan Farashahi Yazd 3, Ali Moradi 4, Hassan Mozaffari-Khosravi 2,5, Mojgan Amiri 1,2, Hamidreza Raeisi-Dehkordi 1,2, Fatemeh Moghtaderi 1,2, Alireza Zimorovat 1,2, Seyed Ali Yasini Ardakani 6, Amin Salehi-Abargouei 1,2* ORCID logo

1 Nutrition and Food Security Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
2 Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
3 Stem Cell Biology Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
4 Department of Biochemistry and Molecular Biology, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
5 Yazd Diabetic Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
6 Department of Food Science and Technology, Islamic Azad University, Yazd, Iran
*Corresponding Author: Amin Salehi-Abargouei, Email: abargouei@ssu.ac.ir

Abstract

Introduction: Cholesteryl ester transfer protein (CETP) is a key regulating enzyme in the lipid metabolism pathway, and its gene polymorphism may be a candidate for modulating the metabolic responses to dietary intervention. We thus examined whether the effects of the CETP TaqIB polymorphism on metabolic profiles were modified by dietary plant oils.
Methods: This is a retrospective analysis of data collected during a randomized triple-blind cross over trial. A total of 95 patients with type 2 diabetes and 73 non-diabetes individuals completed a 9-weekof the intake of sesame, canola and sesame-canola oils. Blood samples were collected at the beginning and at the end of each intervention period for biochemical analysis. Genotyping was done using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method.
Results: In diabetes patients, B1B1 homozygotes of the CETP TaqIB polymorphism compared with B2 carriers (B1B2 + B2B2) had significantly lower diastolic blood pressure, apoB and apoB: apoA-1,and higher Lp(a) after the intake of sesame-canola oil, as well as lower insulin and HOMA-IR after the intake of sesame oil. There was also a significant effect of genotype on adjusted changes of apoB, apoB: apoA-1, insulin, HOMA-IR and QUICKI. A significant genotype-dietary oils combined effects were observed for diastolic blood pressure, and LDL: HDL, TC: HDL and TG: HDL ratios in diabetes patients. No independent or combined effects of dietary oils and genotypes on outcomes were found in healthy people.
Conclusion: There was a modulatory effect of the CETP TaqIB polymorphism on some metabolic traits in response to plant oils in patients with diabetes. Taken together, the intake of sesame-canola and canola oils showed more favorable effects in diabetes patients with B1B1 genotype. Future investigations are needed to confirm these results.
Keywords: Cholesterol Ester Transfer Proteins, Diabetes Mellitus, Sesame Oil, Canola Oil, Sesame-Canola Oil, Polymorphism
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