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Submitted: 22 Jan 2022
Revision: 09 May 2022
Accepted: 21 May 2022
ePublished: 25 Jun 2022
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J Cardiovasc Thorac Res. 2022;14(3): 147-152.
doi: 10.34172/jcvtr.2022.20
PMID: 36398051
PMCID: PMC9617059
Scopus ID: 85140387711
  Abstract View: 461
  PDF Download: 302
  Full Text View: 37

Original Article

Triglyceride-to-glucose index to detect a non-dipping circadian pattern in newly diagnosed hypertensive patients

Faysal Şaylık 1* ORCID logo, Tufan Çınar 2, Murat Selçuk 2, Tayyar Akbulut 1

1 Department of Cardiology, Van Training and Research Hospital, 65100, Van, Turkey
2 Department of Cardiology, Sultan 2. Abdulhamid Han Training and Research Hospital, 34100, Istanbul, Turkey
*Corresponding Author: Corresponding Author: Faysal Şaylık, Email: , Email: faysalsaylik@gmail.com

Abstract

Introduction: In this investigation, we aimed to explore the relationship between the triglyceride-glucose (TyG) index and the non-dipping blood pressure (BP) pattern in newly diagnosed hypertensive patients.

Methods: In this retrospective study, 216 consecutive newly diagnosed hypertensive patients who had undergone 24-hour ambulatory blood pressure (ABPM) monitoring and had not received anti-hypertensive drugs were included. Non-dipping status was evaluated by a 24-h ABPM monitoring in all patients. We categorized the patients into two groups as; dippers (n=104 cases) and non-dippers (n=112 cases). The TyG index was derived from the fasting triglyceride and fasting glucose levels using the formula; ln[fasting triglyceride (mg/dL) × fasting glucose (mg/dL)/2].

Results: Non-dipper group had a higher TyG index than the dipper group. The TyG was an independent predictor of non-dipping BP in hypertensive individuals, according to multivariable analysis. The TyG index was negatively associated with a decrease in both systolic and diastolic BP during the nighttime. The ideal cutoff value of the TyG index in detecting non-dipping status was≥9.01 with 74.1% sensitivity and 71.2% specificity. A ROC comparison indicated that the area under the curve value of TyG index was superior to fasting triglyceride, fasting glucose, and homeostasis model assessment of IR (HOMA-IR) in detecting non-dipping BP.

Conclusion: The TyG index was an independent predictor of non-dipping status in newly diagnosed hypertensive patients who had undergone 24-hour ABPM monitoring and had not received anti-hypertensive drugs. As a simple and easily obtained parameter, the TyG index can be used to detect such pattern among these patients.

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Full Text View: 37

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